Anti-ulcer Activity of Methanolic Extract of Hibiscus Rosa Sinensis Leaves

Objective: The antiulcer activity of various extracts of Hibiscus rosa sinensis leaves was evaluated in pyloric ligation induced gastric ulcer in albino rats. Method: The leaves extracts were prepared by cold maceration process with petroleum ether, alcohol and water separately. Results: Oral administration of aqueous and alcohol extracts (200 and 400 mg/kg) of Hibiscus rosa sinensis leaves were evaluated for antiulcer activity and compared with the standard drug, omeprazole (50 mg/kg). From the results, it can be concluded that the aqueous extract of Hibiscus rosa sinensis roots (400 mg/kg) showed highly significant (P<0.001) dose-dependent antiulcer activity. Conclusion: These results lend scientific support for the plant as folk medicine.